Which of the following is a likely cause of duodenal ulceration in patients who are Helicobacter pylori negative?
A. Bordetella pertussis infection
B. Zollinger-Ellison syndrome
C. Pheochromocytoma
D. Mercury poisoning
E. None of the above
MED2KNOW QUIZ WIZ – 25
A
E
B
E
B!
THE CORRECT ANSWER : B – ZOLLINGER – ELLISON SYNDROME
EXPLANATION : Zollinger-Ellison syndrome is caused by a gastrin-producing endocrine tumor, which is usually in the pancreas or small bowel and leads to marked hyperacidity. This syndrome usually gives rise to severe peptic ulcer disease with multiple, concomitant duodenal ulcers that are resistant to conventional acid suppressive therapy. The other conditions listed are not known to be associated with an increased risk for peptic ulcer.